If you’re craving a comforting, hearty dish that brings together the bold flavors of Tex-Mex with a creamy, cheesy finish, then this John Wayne Casserole Recipe is about to become your new go-to. With layers of seasoned ground beef, zesty Rotel tomatoes, sweet corn, and a luscious cream cheese topping all nestled on a biscuit crust, this casserole is pure soul food at its best. It’s perfect for sharing around the table with family or friends and offers a satisfying, crowd-pleasing meal that warms you from the inside out.

John Wayne Casserole Recipe - Recipe Image

Ingredients You’ll Need

These straightforward ingredients are the heart and soul of the John Wayne Casserole Recipe, each adding a vital note of flavor, texture, and richness. From the savory ground beef to the cheesy blend, every component plays its part in creating this unforgettable dish.

  • 1 lb lean ground beef: The protein-packed base that absorbs all the spices and flavors brilliantly.
  • 1 cup diced yellow onion: Adds a sweet, aromatic depth to the savory meat mixture.
  • 20 oz Rotel diced tomatoes and green chilies, drained: Brings a zesty kick and a burst of color to the dish.
  • 12 oz canned corn, drained: Adds subtle sweetness and texture to balance the spices.
  • 1 oz taco seasoning (about 2-3 tablespoons): Packs the classic Tex-Mex punch that ties all the flavors together.
  • 1 cup water (for beef mixture): Keeps the filling moist and helps the seasoning blend in smoothly.
  • 3 cups Bisquick mix: The secret to a quick and easy biscuit crust that adds a delightful soft and slightly crispy layer beneath the savory filling.
  • 1 cup water (for biscuit crust): Necessary to create the biscuit dough.
  • 7.5 oz Philadelphia whipped chive cream cheese: Adds a rich, creamy tang with a touch of herby brightness.
  • 1/2 cup mayonnaise: Helps make the creamy layer luxuriously smooth and rich.
  • 1 tbsp garlic powder: Infuses the creamy topping with a warm, savory undertone.
  • 1/2 tsp salt: Enhances all the flavors and balances the richness.
  • 2 cups shredded mozzarella and cheddar cheese blend: Gives the casserole that melty, golden, irresistible gooey cheese blanket.

How to Make John Wayne Casserole Recipe

Step 1: Preheat Your Oven

Start by setting your oven to 325°F (163°C). This moderate temperature ensures your casserole bakes evenly, giving the biscuit crust time to cook through while the layers meld into cheesy perfection.

Step 2: Cook the Ground Beef

Heat a large sauté pan over medium-high and crumble the lean ground beef as it cooks. Brown the meat fully, which should take about 6-8 minutes, then drain off any excess grease. This step builds the rich, meaty foundation for your casserole filling.

Step 3: Add Seasonings and Vegetables

Pour in 1 cup of water and sprinkle the taco seasoning over the browned beef. Let it simmer gently for about 4 minutes so those bold spices mingle deeply with the meat. Then, stir in your diced onions, drained Rotel tomatoes with green chilies, and corn. Reduce the heat to low to keep everything warm and allow the flavors to marry beautifully.

Step 4: Prepare the Biscuit Crust

In a mixing bowl, combine 3 cups of Bisquick mix with 1 cup water, stirring until a sticky dough forms. Spread this dough evenly into a buttered or greased 9×13-inch baking dish to create a soft yet slightly crisp biscuit base for your casserole.

Step 5: Assemble the Layers

Pour your rich ground beef mixture over the biscuit crust, spreading it out evenly. In a separate bowl, blend together the whipped chive cream cheese, mayonnaise, garlic powder, and salt until smooth and creamy. Dollop this luscious mixture on top of the beef and spread it with a spatula. Finally, sprinkle your shredded mozzarella and cheddar cheese blend over the very top.

Step 6: Bake to Perfection

Slide the casserole into your preheated oven and bake for 40 minutes. You’ll know it’s ready when the cheese is bubbly and golden and the biscuit crust edges look beautifully browned. The aroma wafting through your kitchen will be absolutely irresistible!

Step 7: Let It Set and Serve

Once out of the oven, give the casserole a few minutes to rest. This helps it set nicely so your slices hold together perfectly, making serving a breeze. Then, grab your favorite plate, dish it out, and get ready to enjoy every comforting bite.

How to Serve John Wayne Casserole Recipe

John Wayne Casserole Recipe - Recipe Image

Garnishes

Simple garnishes like chopped fresh cilantro, sliced green onions, or a dollop of sour cream add freshness and a little zing to the richness of this casserole. A sprinkle of crushed tortilla chips can add a delightful crunch too.

Side Dishes

This casserole stands beautifully on its own, but if you want to round out the meal, a crisp green salad with a light vinaigrette or some steamed vegetables are perfect companions. For extra heartiness, warm tortillas or Mexican rice make excellent side options.

Creative Ways to Present

For a fun twist, serve portions in individual ramekins or small cast iron skillets for a charming rustic presentation. You can also top each serving with avocado slices or fresh salsa to brighten the dish and add a colorful flair.

Make Ahead and Storage

Storing Leftovers

After enjoying your casserole, transfer any leftovers to an airtight container and refrigerate them. They’ll stay fresh for up to 3 days, making it easy to savor this comforting meal again without extra effort.

Freezing

If you want to save some for later, this John Wayne Casserole Recipe freezes wonderfully. Wrap it tightly in plastic wrap and foil or place it in a freezer-safe container, and it should keep well for up to 2 months. Just thaw it overnight in the fridge before reheating.

Reheating

To reheat, place the casserole in a preheated oven at 350°F (175°C) for about 20 minutes or until heated through. You can also microwave individual slices on medium power, but baking helps keep the biscuit crust crisp and the cheese deliciously melted.

FAQs

Can I use a different kind of cheese for the topping?

Absolutely! While mozzarella and cheddar blend offers great meltiness and flavor, you can swap in Monterey Jack, pepper jack for a little heat, or even a Mexican cheese blend if you prefer. Just go with what you love or have on hand.

Is this casserole spicy?

It has a mild to moderate spice level thanks to the Rotel tomatoes with green chilies and taco seasoning. If you prefer it less spicy, drain the tomatoes well and adjust the taco seasoning to your taste, or go for a mild version.

Can I make this recipe vegetarian?

Definitely! Substitute the ground beef with firm tofu, tempeh, or your favorite plant-based ground meat alternative. The rest of the ingredients remain the same, and the layers of flavor will still shine.

What’s the best way to get a crisp biscuit crust?

Using a greased baking dish and spreading the Bisquick dough evenly helps. Also, baking at a moderate temperature as given will ensure the crust cooks through and edges crisp nicely without burning.

Can I prepare this casserole a day ahead?

Yes! You can assemble everything up to the point before baking, cover tightly, and refrigerate overnight. When ready, bake as directed, adding a few extra minutes if needed since it’s chilled straight from the fridge.

Final Thoughts

There’s something truly special about the John Wayne Casserole Recipe that makes it feel like a warm hug in meal form. It’s easy to prepare, full of adventurous flavors, and downright delicious whether for a casual dinner or a family gathering. Give it a try soon—you won’t regret having this hearty, cheesy, flavor-packed dish in your recipe rotation!

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John Wayne Casserole Recipe

5 Stars 4 Stars 3 Stars 2 Stars 1 Star 4.2 from 44 reviews
  • Author: admin
  • Prep Time: 20 minutes
  • Cook Time: 50 minutes
  • Total Time: 1 hour 10 minutes
  • Yield: 6 servings
  • Category: Casserole
  • Method: Baking
  • Cuisine: Tex-Mex

Description

John Wayne Casserole is a hearty, flavorful baked dish featuring a savory ground beef mixture layered over a buttery biscuit crust, topped with a creamy chive cream cheese mixture and melted cheese blend. Perfect for comforting family dinners, this casserole delivers a satisfying combination of Tex-Mex flavors and cheesy goodness.


Ingredients

Scale

Beef Mixture

  • 1 lb lean ground beef
  • 1 cup diced yellow onion
  • 20 oz Rotel diced tomatoes and green chilies, drained
  • 12 oz canned corn, drained
  • 1 oz taco seasoning (about 23 tablespoons)
  • 1 cup water

Biscuit Crust

  • 3 cups Bisquick mix
  • 1 cup water

Cream Cheese Topping

  • 7.5 oz Philadelphia whipped chive cream cheese
  • 1/2 cup mayonnaise
  • 1 tbsp garlic powder
  • 1/2 tsp salt

Cheese Topping

  • 2 cups shredded mozzarella and cheddar cheese blend


Instructions

  1. Preheat oven: Set your oven to 325°F (163°C) to prepare for baking the casserole.
  2. Cook ground beef: In a large sauté pan over medium-high heat, add the ground beef and crumble it as it cooks until browned. Drain excess grease from the pan.
  3. Add seasonings and vegetables: Stir in 1 cup water and taco seasoning, then simmer for 4 minutes. Add diced onions, drained Rotel tomatoes and green chilies, and drained corn. Mix well, reduce heat to low, and keep warm.
  4. Prepare biscuit crust: In a mixing bowl, combine 3 cups Bisquick mix and 1 cup water, stirring until a sticky dough forms. Spread the dough evenly into a greased 9×13-inch baking dish.
  5. Assemble layers: Pour the cooked ground beef mixture over the biscuit layer, spreading evenly. In a separate bowl, cream together the whipped chive cream cheese, mayonnaise, garlic powder, and salt until smooth. Dollop and spread this mixture over the beef layer. Sprinkle shredded mozzarella and cheddar cheese blend on top.
  6. Bake: Place the casserole in the preheated oven and bake for 40 minutes until bubbly and golden on top.
  7. Serve: Remove from oven and let sit for a few minutes before slicing and serving to allow the casserole to set.

Notes

  • Use lean ground beef to reduce excess grease in the casserole.
  • Ensure the biscuit dough is spread evenly for consistent crust thickness.
  • Letting the casserole rest after baking helps it set better for cleaner slices.
  • You can substitute Rotel with diced tomatoes and green chilies if preferred.
  • For a spicier kick, add extra taco seasoning or jalapeños to the beef mixture.

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